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Samip N. Patel MD Marc A. Cohen MD Babak Givi MD Benjamin J. Dixon MD Ralph W. Gilbert MD Patrick J. Gullane MD Dale H. Brown MD Jonathan C. Irish MSc MD John R. de Almeida MSc MD Kevin M. Higgins MSc Danny Enepekides MSc Shao Hui Huang John Waldron MD Brian O'Sullivan MD Wei Xu PhD Susie Su MSc David P. Goldstein MSc MD 《Head & neck》2016,38(Z1):E658-E664
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Translational treatment paradigm for managing non‐unions secondary to radiation injury utilizing adipose derived stem cells and angiogenic therapy 下载免费PDF全文
Alexis Donneys MD MS Jordan T. Blough BS Noah S. Nelson BS Joseph E. Perosky MS Sagar S. Deshpande BS Stephen Y. Kang MD Peter A. Felice MD Christian Figueredo BS Jonathan R. Peterson BS Kenneth M. Kozloff PhD Benjamin Levi MD Douglas B. Chepeha MD Steven R. Buchman MD 《Head & neck》2016,38(Z1):E837-E843
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Clinical outcomes with transoral robotic surgery for supraglottic squamous cell carcinoma: Experience of a French evaluation cooperative subgroup of GETTEC 下载免费PDF全文
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Adipose tissue at entheses: the innervation and cell composition of the retromalleolar fat pad associated with the rat Achilles tendon 总被引:1,自引:1,他引:0
This study set out to determine whether the fat pad at the attachment of the Achilles tendon has features enabling it to function as an immune organ and a mechanosensory device, and to be a source of pain in insertional tendon injuries. Sections for histology and immunohistochemistry were cut from the Achilles tendon enthesis organ of 1 day old, 1 month, 4 month and 24 month old rats. For fluorescence and peroxidase immunohistochemistry, cryosections were labelled with primary antibodies directed against PGP9.5, substance P, neurofilament 200, calcitonin gene related peptide, CD68, CD36, myeloid related protein 14, actin and vinculin. The fat pad contained not only adipocytes, but also fibrous tissue, mast cells, macrophages, fibroblasts and occasional fibrocartilage cells. It was richly innervated with nerve fibres, some of which were likely to be nociceptive, and others mechanoreceptive (myelinated fibres, immunoreactive for neurofilament 200). The fibres lay between individual fat cells and in association with blood vessels. In marked contrast, the enthesis itself and all other components of the enthesis organ were aneural at all ages. The presence of putative mechanoreceptive and nociceptive nerve endings between individual fat cells supports the hypothesis that the fat pad has a proprioceptive role monitoring changes in the insertional angle of the Achilles tendon and that it may be a source of pain in tendon injuries. The abundance of macrophages suggests that the adipose tissue could have a role in combating infection and/or removing debris from the retrocalcaneal bursa. 相似文献
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Hernández A Sierra A Valdiosera R Florán B Erlij D Aceves J 《Neuroscience letters》2007,425(3):188-191
The effects of D1/5 dopamine agonists on spontaneous excitatory postsynaptic currents (sEPSCs) were studied in neurons of the rat globus pallidus using whole-cell recordings in the presence of TTX and bicuculline. In this condition, CNQX abolished the sEPSCs, indicating that they were solely mediated by AMPA receptors. SKF 38393, a D1-like agonist, increased the frequency but not the amplitude of the sEPSCs, suggesting a presynaptic site of action. The increase in frequency was blocked by SCH 23390, a D1/5 antagonist. Quinpirole, a D2-like agonist, decreased the frequency but did not affect the amplitude of the synaptic currents. SKF 38393 increased the frequency of sEPSCs currents, even in presence of quinpirole, indicating that D1/5- and D2-like receptors independently modulate glutamate release upon a single neuron. The results suggest that the dopaminergic control of the glutamate transmission in the globus pallidus may play a role in processing cortical information in the indirect pathway of the basal ganglia. 相似文献